Once you have your manuscript on your iPad, read and edit away. I highlight words or text I want to delete, without adding an explanatory note. If something's highlighted and there's no note, it means delete. If I want to change one word, I'll simply add a note to that word; no need to highlight anything. If I want to rewrite severals words, even a paragraph, I first highlight the text, then add a note with the changes I want made.
This is a very clever idea, especially if you use Scrivener.
Compile your ebook in Scrivener, then send it to your Kindle email address, and edit away.